Imidazole Suppliers, Traders, dealers in Mumbai, Maharashtra, India

Imidazole

Imidazole is a versatile heterocyclic compound, characterized by a five-membered ring containing two nitrogen atoms. With its unique electronic structure, imidazole exhibits both acidic (pKₐ ≈ 6.95) and basic (pKₐ ≈ 14.5) properties, making it invaluable in chemistry, biochemistry, and industrial applications. Due to its high purity, thermal stability, and favorable solubility profile, imidazole is widely used as a buffer in biochemical systems, an intermediate in pharmaceuticals, an agrochemical reagent, and a corrosion inhibitor. This document details the product specifications, structure, handling, applications, FAQs, and why choosing Shakti Chemicals adds strategic value for industrial and laboratory users.

What Is Imidazole?

Imidazole (CAS No. 288-32-4) is a five-membered heterocycle with the molecular formula C₃H₄N₂ and molecular weight 68.08 g/mol. It consists of three carbon atoms and two nitrogen atoms positioned at non-adjacent sites in the ring—specifically, one pyrrole-like NH and one pyridine-like nitrogen. This duality lends imidazole amphoteric behavior: it can both donate and accept protons, with its conjugate acid pKₐ around 6.95 at 25 °C.

Imidazole appears as a white to off-white crystalline powder, melting at 88–91 °C and boiling around 256 °C under atmospheric pressure. Its low vapor pressure (<1 mmHg at 20 °C) and moderate flash point (~145 °C) make it relatively safe for solid storage. Soluble in water and many organic solvents, it often serves as a buffering agent in biochemical applications (optimal in pH range 6.2–7.8), and is instrumental in protein studies, enzyme assays, and nucleic acid stabilization.

Beyond biochemistry, imidazole’s nucleophilicity and ring stability make it a key building block in organic synthesis, notably in antifungal pharmaceuticals (e.g., ketoconazole), agrochemical formulations, and industrial corrosion inhibitors. It also functions as a precursor for other heterocycles and ligands in coordination chemistry.

Chemical Specifications

Specifications

Purity: ≥ 99 %, determined by titration or HPLC; water ≤ 0.2 %, ignition residue ≤ 0.1 %.

Physical Properties:

-Appearance: off-white crystalline.

-Melting point: typically 88–91 °C; commercial meets within spec.

-Boiling point: ~256 °C.

-pH of 5 % solution: 9.5–11.0 .

Moisture Content: ≤ 0.5 %.

Identifications: Conforms to chemical identity per SMILES “c1c[nH]cn1”, InChI key RAXXELZNTBOGNW-UHFFFAOYSA-N.

Handling and Storage

Storage Conditions:

Store in sealed containers, in cool (< 25 °C), dry, and well-ventilated area.

Recommended storage class: 6.1C (toxic solid).

Avoid sources of ignition and oxidative conditions; imidazole dust may pose an explosion hazard in air/dust mixtures.

Handling Precautions:

Use in chemical fume hood with good general ventilation.

Avoid ingestion, inhalation, or contact with skin/eyes.

Wear PPE: gloves, safety goggles, N95 respirator or equivalent, lab coat.

Spill Procedures:

Contain spills; sweep and collect powder into suitable containers.

Clean with inert absorbent; avoid dust spread.

Prevent entry into drains or waterways.

Fire-Fighting:

Combustible solid: extinguish with water spray, foam, dry powder .

Hazardous combustion: NOₓ, CO, HCN, ammonia may be released.

Structure of Imidazole

Imidazole comprises a planar five-membered aromatic ring. Two nitrogens are positioned at the 1- and 3-positions: one is a pyrrole-type NH that can donate a proton; the other (pyridine-like) can accept one. This duality enables acid/base behavior and strong hydrogen bonding.

Structural representation:

SMILES: c1c[nH]cn1; InChI: 1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5).

Why Choose Shakti Chemicals

Shakti Chemicals is an ISO 9001-2015 certified suppliers, exporters with over 40 years in supplying heterocyclic and photochemical raw materials. Choosing Shakti Chemicals in Mumbai, Maharashtra delivers value as:

Extensive network of suppliers, traders, dealers, importers, and distributors ensuring smooth global logistics.

High-Yield, consistent-quality capex manufacturing with in-house QC and external standards.

Competitive pricing and batch traceability for clients in chemical, pharmaceutical, agrochemical, and oilfield sectors.

Expert technical support and customized packaging options.

Proven track record in exporting to UAE, Malaysia, Australia, South Africa, and across Americas.

Product Pack Size

Imidazole is typically supplied in the following pack sizes:

25 kg and 50 kg multi-layer paper bags with poly-inner liner.

200–250 kg sealed steel or plastic drums.

Secondary options (e.g., 1 kg/5 kg bottles, 10 kg packs) available on request for analytical-grade use.

Applications of Imidazole

Biochemical Buffering – Ideal at pH 6.2–7.8; supports enzyme assays and protein purification.

Pharma Synthesis – Intermediate in antifungals (e.g., clotrimazole), antihistamines, and ACE inhibitors.

Agrochemical Intermediates – Used in pesticide and herbicide formulations.

Corrosion Inhibition – Adsorbs onto steel, protective in cooling systems.

Ligand Chemistry – Base component for metal-complex catalysts.

Histamine Analogue – Biochemical studies due to structural similarity.

Analytical Reagents – Component in chromatography, buffer systems, and spectrometry.

Resins & Polymers – Catalyst or cross-linker in specialty resin formulations.

Photographic & Oilfield Chemicals – Intermediate for dyes, surfactants, and drilling additives.

FAQs

What grades are available?

Industrial grade (≥ 99 %) and ACS/Pharma grade (> 99.5 %, water ≤ 0.2 %).

What is the pH of imidazole solution?

~9.5–11 for a 5 % aqueous solution at 25 °C.

Is imidazole hygroscopic?

Moderately; packaging with liners and storing in desiccated environments is recommended.

Hazards associated?

Harmful if swallowed, causes severe eye/skin burns, may damage an unborn child.

What PPE is needed?

Gloves, goggles, lab coat, N95 respirator; use within a fume hood .

What’s the shelf life?

Stable for over 2 years if stored sealed, dry, and cool (< 25 °C).

Does it dissolve easily?

Yes: fully soluble in water; also soluble in ethanol, methanol, DMSO, etc.

What is its role in lost-circulation drilling?

Functions as a corrosion inhibitor as well as pH buffer in drilling fluids.

Is it hazardous to aquatic organisms?

Low aquatic toxicity; read biodegrades readily (~86 % in 19 days) .

Can it contact food?

No—use not advised for direct skin, food, or cosmetic contact.

Imidazole offers a powerful combination of chemical stability, amphoteric reactivity, and multifunctionality—attributes that make it indispensable in pharmaceutical synthesis, biochemical assays, corrosion inhibition, and agrochemical production. With rigorous industry and analytical-grade offerings, Shakti Chemicals provides a reliable global supply backed by robust quality standards, extensive packaging and logistical support, and expert technical service. Whether your needs are for high-purity buffers, heterocyclic intermediates, or industrial reagents, imidazole from Shakti Chemicals ensures consistent performance and value across critical applications. Choose innovation, quality, and trust—choose Shakti Chemicals in India.

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